IQGAP1 and IGFBP2

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IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling.

Calmodulin regulates diverse Ca2+-dependent cellular processes, including cell cycle progression and cytoskeletal rearrangement. A recently identified calmodulin-binding protein, IQGAP1, interacts with both actin and Cdc42. In this study, evidence is presented that, in the absence of Ca2+, IQGAP1 bound to Cdc42, which maintained Cdc42 in the active GTP-bound state. Addition of Ca2+ both directl...

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IQGAP1 Integrates Ca/Calmodulin and Cdc42 Signaling*

Calmodulin regulates diverse Ca-dependent cellular processes, including cell cycle progression and cytoskeletal rearrangement. A recently identified calmodulin-binding protein, IQGAP1, interacts with both actin and Cdc42. In this study, evidence is presented that, in the absence of Ca, IQGAP1 bound to Cdc42, which maintained Cdc42 in the active GTP-bound state. Addition of Ca both directly abro...

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ژورنال

عنوان ژورنال: Journal of Neuropathology and Experimental Neurology

سال: 2007

ISSN: 0022-3069

DOI: 10.1097/nen.0b013e31804567d7